133 research outputs found

    Fault tolerant packet-switched network design and Its sensitivity

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    Reliability and performance for telecommunication networks have traditionally been investigated separately in spite of their close relation. A design method integrating them for a reliable packet switched network, called a proofing method, is presented. Two heuristic design approaches (max-average, max-delay-link) for optimizing network cost in the proofing method are described. To verify their effectiveness and applicability, they are compared numerically for three example network topologies. The sensitivity of these two methods is examined with respect to changes in traffic demand and in link reliability. The design sensitivity to variation of input data is examined by changing the predicted probability of link failure, and by increasing the network traffic over the predicted value. The resulting analysis shows relative insensitivity of solutions generated by the two design methods to input data</p

    Advances and Analysis on Reducing Webpage Response Time with Effect of Edge Computing

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    Modern webpages consist of many rich objects dynamically produced by servers and client terminals at diverse locations, so we face an increase in web response time. To reduce the time, edge computing, in which dynamic objects are generated and delivered from edge nodes, is effective. For ISPs and CDN providers, it is desirable to estimate the effect of reducing the web response time when introducing edge computing. Therefore, in this paper, we derive a simple formula that estimates the lower bound of the reduction of the response time by modeling flows obtaining objects of webpages. We investigate the effect of edge computing in each webpage category, e.g., News and Sports, using data measured by browsing about 1,000 popular webpages from 12 locations in the world on PlanetLab

    Performance Analysis of Signaling Delay for Wireless Cellular Networks

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    In wireless cellular networks, signaling traffic such as location update, paging and handoff due to the user\u27s mobility takes a considerable portion of the total traffic load. In addition, the maximum allowable delays may be different among the signaling packets. In this paper, we present an analytical model for evaluating a total processing delay of signaling packets of wireless cellular networks, which integrates the delays of the radio channel and the processing delay at the wired portion. Through numerical examples, we show that priority processing is effective for reducing the handoff processing delays. We also evaluate the delay difference among cells according to their position within the location area, and the influence of number of terminals upon the processing delays

    Microstructure, Mechanical Properties and Fracture Behavior of α Particle Irradiated Type 316 Stainless Steel

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    The present work is a research of the effect of helium on the microstructure, mechanical properties and fracture behaviors of a type 316 austenitic steel. Helium implantation was performed by 30-MeV α-particle injection on very small size specimens, using a cyclotron. Average helium content in a He-deposited region was up to 2000 appm He. In the case of 2000appm He implantation, intergranular fracture was sometimes observed on the helium deposited region after tensile test at room temperature. At elevated temperature test, however, this material showed the transition of fracture mode from transgranular-ductile fracture at 773K to intergranular fracture at 873. In the case of 500 appm He implantation, the transition of fracture mode was recognized at a temperature range of 873K to 973K

    Pharmacokinetics of Mirabegron, a β3-Adrenoceptor Agonist for Treatment of Overactive Bladder, in Healthy Japanese Male Subjects: Results from Single- and Multiple-Dose Studies

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    BACKGROUND: Mirabegron is a human β(3)-adrenoceptor agonist for the treatment of overactive bladder. The pharmacokinetic profile of mirabegron has been extensively characterized in healthy Caucasian subjects. OBJECTIVE: The objective of this study was to evaluate the pharmacokinetics, dose-proportionality, and tolerability of mirabegron following single and multiple oral doses in healthy Japanese male subjects. The results were compared with those reported in non-Japanese (primarily Caucasian) subjects. METHODS: Two studies were conducted. In a single-blind, randomized, placebo-controlled, parallel-group, single- and multiple-ascending dose study (Study 1), mirabegron oral controlled absorption system (OCAS) tablets were administered at single doses of 50, 100, 200, 300, and 400 mg, with eight subjects (six active, two placebo) per dose group (Part I), and once daily for 7 days at 100 and 200 mg with 12 subjects (eight active, four placebo) per group (Part II). In an open-label, three-period, single-ascending dose study (Study 2), mirabegron OCAS was administered to 12 subjects at 25, 50, and 100 mg in an intra-subject dose-escalation design. Plasma and/or urine samples were collected up to 72 h after the first and last dose and analyzed for mirabegron. Pharmacokinetic parameters were determined using non-compartmental methods. Tolerability assessments included physical examinations, vital signs, 12-lead electrocardiogram, clinical laboratory tests (biochemistry, hematology, and urinalysis), and adverse event (AE) monitoring. RESULTS: Forty and 24 young male subjects completed Part I and II, respectively, of Study 1. Twelve young males completed Study 2. After single oral doses (25–400 mg), maximum plasma concentrations (C(max)) were reached at approximately 2.8–4.0 h postdose. Plasma exposure (C(max) and area under the plasma concentration–time curve) of mirabegron increased more than dose proportionally at single doses of 25–100 mg and approximately dose proportionally at high doses of 300 and 400 mg. A more than dose proportional increase in plasma exposure was noted in the body of the same individual. Mirabegron accumulated twofold upon once-daily dosing relative to single-dose data. Steady state was reached within 7 days. Mirabegron was generally well-tolerated at single doses up to 400 mg and multiple doses up to 200 mg. The AE with the highest incidence was increased pulse rate at 400 mg in Study 1. CONCLUSIONS: Mirabegron OCAS exhibits similar single- and multiple-dose pharmacokinetic characteristics and deviations from dose proportionality in healthy Japanese male subjects compared with those observed in non-Japanese (primarily Caucasian) subjects in previous studies

    Candida albicans

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    Genotypes of Candida spp. isolated from exhalation of 20 dolphins, 11 water samples from captive pools, and 24 oral cavities of staff members in an aquarium using a combination of multiple drug resistance 1 gene (MDR1) and the internal transcribed spacer (ITS) 1 5.8s-ITS 2 regions of ribosomal RNA gene (ITS rDNA) sequences were studied. The holding ratios of the dolphins, captive pools, and staff members were 70, 90, and 29%, respectively. Isolated pathogenic yeast species common to the dolphins and environments were Candida albicans and C. tropicalis. Identical genotypes in both Candida spp. based on the combination of MDR1 and ITSrDNA were found in some dolphins, between a dolphin and a staff, among dolphins and environments, and among environments. The results indicated the diffusion and exchange of pathogenic yeasts at the aquarium among dolphins and environments. The isolates at the aquarium showed higher rates of resistance to azole antifungals compared to reference isolates
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